HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 135529059, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 21918881 | HCID 21918881 | — |
| Reactant | 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzene-1-sulfonyl chloride | HCID 135430159 | — |
| Reactant | HCID 136351949 | HCID 136351949 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 135529059 | HCID 135529059 | — |
Reaction Steps
By the same method, starting with 0.4 g (0.97 mmol) of 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride, 390 mg of triethylamine and 0.86 g (2.99 mmol) of 4-dimethoxyphosphorylmethyl-piperazine trifluoroacetate, 321 mg (53%) of 2-[2-ethoxy-5-(4-dimethoxyphosphoryl-methyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are obtained. Rf=0.4 (dichloromethane/methanol=20:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566360B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-2f5200467f1a4fb399b6724f88e6bf91 |
| Source note | uspto-grants-2003_05 |