Brofoxine → 6-(2-Chlorophenyl)-4,4-dimethyl-1H-benzo[D][1,3]oxazin-2(4H)-one

Participants

Role	Name	HCID	Charge
Reactant	Brofoxine	HCID 30630	—
Reactant	2-Chlorophenylboronic acid	HCID 2734322	—
Product	6-(2-Chlorophenyl)-4,4-dimethyl-1H-benzo[D][1,3]oxazin-2(4H)-one	HCID 9860721	—

Reaction Steps

Prepared according to Procedure A from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 2-chlorophenyl boronic acid. White solid: mp 181-182° C.; MS (ESI) m/z 288 ([M+H]+, 70%); Anal. Calc. For C16H14ClNO2: C, 66.79 H, 4.90, N, 4.87. Found: C, 66.78, H, 4.82, N, 4.55

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06566358B2
Source dataset	uspto-grants-2003_05
ORD ID	ord-088d0961615e4522acebc2d5b9d03826
Source note	uspto-grants-2003_05