HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)boronic acid → 6-(3-Chlorophenyl)4,4-diethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Reactant | 4,4-Diethyl-1,4-dihydro-6-iodo-2H-3,1-benzoxazin-2-one | HCID 22021892 | — |
| Product | 6-(3-Chlorophenyl)4,4-diethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-one | HCID 10267815 | — |
Reaction Steps
Prepared from 4,4-diethyl-6-iodo-1,4-dihydrobenzo[d][1,3]oxazin-2-one and 3-chlorophenyl boronic acid according to Procedure A. White solid: mp 150-151° C. 1H-NMR (CDCl3) δ8.52 (s, 1H, D2O exchangeable), 7.50 (s, 1H), 7.31-7.44 (m, 4H) 7.16 (d, 1H, J=1.5 Hz), 6.89 (d, 1H, J=8.2 Hz), 2.03 (m, 4H), 0.94 (t, 6H, J=7.4 Hz); MS (EI) m/z 315(M+, 53%). Anal. Calc. For C18H18ClNO2: C, 68.46, H, 5.75, N, 4.44. Found: C, 68.16, H, 5.81, N, 4.32.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566358B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-784aad7937784f4ebaac403518339d38 |
| Source note | uspto-grants-2003_05 |