1-Bromo-3,5-difluorobenzene → 6-(3,5-Difluoro-phenyl)-4,4dimethyl-1,4dihydrobenzo-[d][1,3]oxazin-2-one

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-3,5-difluorobenzene	HCID 136313	—
Reactant	(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid	HCID 10987806	—
Product	6-(3,5-Difluoro-phenyl)-4,4dimethyl-1,4dihydrobenzo-[d][1,3]oxazin-2-one	HCID 9835615	—

Reaction Steps

Prepared according to procedure B from (4,4-dimethyl-1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid and 1-bromo-3,5-difluorobenzene. A white solid: mp 218-219° C.; 1H-NMR (DMSO-d6) δ10.4 (s, 1H), 7.67-7.65 (m, 2H), 7.49 (d, 2H, J=7.73 Hz), 7.19 (t, 1H, J=9.29 Hz), 6.96 (d, 1H, J=8.88 Hz), 1.7 (s, 6H); MS (APCI) m/z 290 ([M+H]+, 100%); Anal. Calc. For C16H13F2NO2: C, 66.43, H, 4.53, N, 4.84. Found: C, 66.01, H, 4.46, N, 4.67.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06566358B2
Source dataset	uspto-grants-2003_05
ORD ID	ord-d3f17314d1934ca491d74bf78a07066e
Source note	uspto-grants-2003_05