反应详情

A mixture of γ-phenyl-γ-butyrolactone (10.30 g, 63.5 mmol) and an excess of ammonia was stirred under nitrogen and a dry ice trap for 8 hours. The dry ice trap was removed and after evaporation of the ammonia 11.27 g of a tan solid remained. Recrystallization of the solid from ethyl acetate-hexane gave 4-hydroxy-4-phenyl-butyramide (8.56 g, 75%) as a white solid, mp 85-87° C.

1. customThe dry ice trap was removed
2. customafter evaporation of the ammonia 11.27 g of a tan solid
3. customRecrystallization of the solid from ethyl acetate-hexane