Water → (2S)-2-(1-Benzothiophen-2-ylformamido)-4-methylpentanoic acid

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Reaction Steps

Lithium hydroxide (1.41 g, 59 mmol) was added in one portion to a stirred solution of N-benzo[b]thiophene-2-ylcarbonyl-L-leucine methyl ester (8.99 g, 29.4 mmol) in THF/H2O (1/1, 300 ml). After stirring for 12 hours at room temperature, the mixture was poured into water and acidifed to pH 1 with cHCl and extracted with Et2O (×2). Evaporation under reduced pressure afforded the title compound as a yellow solid, 6.1 g, 71% yield.

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