2-Nitro-4-(trifluoromethanesulfonyl)aniline → 4-(Trifluoromethanesulfonyl)benzene-1,2-diamine

HRID 413243Notes

Reaction equation

HRID 413243 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([C:13]([F:16])([F:15])[F:14])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH2:17])([O-])=O>CCO.[Pd]>[F:15][C:13]([F:14])([F:16])[S:10]([C:8]1[CH:9]=[C:4]([NH2:1])[C:5]([NH2:17])=[CH:6][CH:7]=1)(=[O:11])=[O:12]

Participants

4

Reactant 1

HCID 45294692-Nitro-4-(trifluoromethanesulfonyl)aniline

Product 1

HCID 20634624-(Trifluoromethanesulfonyl)benzene-1,2-diamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Dissolve 2-nitro-4-trifluoromethylsulfonyl-phenylamine (530 mg) in EtOH (50 mL) and hydrogenate over Pd/C (10%) for 6 hours. Filter the mixture and concentrate the filtrate in vacuo to obtain 4-trifluoromethylsulfonyl-benzene-1,2-diamine.

Workup

  1. filtrationFilter the mixture
  2. concentrationconcentrate the filtrate in vacuo

Sources & evidence

ORD record
ord-5ebcd2b36f9149319472542168f59a23
Source dataset
uspto-grants-2003_05
Patent number
US06566367B2

Reaction notes

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