HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-5-(3-methoxyphenyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-(3-Methoxyphenyl)benzimidazolidin-2-one | HCID 22325327 | — |
| Catalyst | Tetramethylammonium chloride | HCID 6379 | — |
| Product | 2-Chloro-5-(3-methoxyphenyl)benzimidazole | HCID 12071665 | — |
Reaction Steps
Heat a mixture of 5-(3-methoxyphenyl)benzimidazolidin-2-one (1.4 g) and tetramethylammonium chloride (ca. 2 g) in phosphorous oxychloride at 100° C. for 8 hours. After cooling, concentrate the mixture in vacuo, triturate with water, and neutralize with ammonium hydroxide. Collect the precipitate and air-dry to obtain 2-chloro-5-(3-methoxyphenyl)benzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566367B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-830417ba0abd4286956031aaf20311f9 |
| Source note | uspto-grants-2003_05 |