HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 178478308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-bromo-3H-imidazo[4,5-b]pyridin-2-ol | HCID 1924413 | — |
| Product | HCID 178478308 | HCID 178478308 | — |
Reaction Steps
Reflux 6-bromo-1,3-dihydro-imidazo[4,5-b]pyridin-2-one (5 g) for 14 h in POCl3 (50 mL). Evaporate the solvent in vacuo, then carefully neutralize with saturated NaHCO3, and extract with EtOAc. Dry over Na2SO4, concentrate under vacuum, and purify by flash chromatography (1 :1 hexanes/EtOAc) to obtain 6-bromo-2-chloro-3H-imidazo[4,5-b]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566367B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-1ab2c821fe32404d9a508e7120e4011c |
| Source note | uspto-grants-2003_05 |