HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413258Generated: October 29, 2026
Ammonia → 6-Chloro-3-nitropyridin-2-ylamine
https://huagongshe.com/reaction/413258
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,6-Dichloro-3-nitropyridine | HCID 85239 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
Reaction Steps
Add sodium carbonate (14 g, 130 mmol) and 2M NH3 in EtOH (20 mL) to a solution of 2,6-dichloro-3-nitropyridine (10 g, 51.8 mmol) in ethanol (115 mL). Heat the mixture at 70° C. for 5 hours. After cooling, remove the excess ethanol in vacuo, and triturate the residue in water. After stirring for 15 minutes, filter the precipitate to obtain 6-chloro-3-nitropyridin-2-yl-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06566367B2 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-e7d626f33aa84e9f8e1219018543feaa |
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| Source note | uspto-grants-2003_05 |
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