HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413276Generated: October 27, 2026
Bis(2-chloroethyl)amine hydrochloride → N,N-bis(2chloroethyl)-N'-phenylsulphamide
https://huagongshe.com/reaction/413276
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| Reactant | 2-(2-Chloroethyl)-5-phenyl-1,2,5-thiadiazolidine-1,1-dioxide | HCID 22390850 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N,N-bis(2chloroethyl)-N'-phenylsulphamide | HCID 22390755 | — |
Reaction Steps
66 g of the product obtained in Step 1 above are added to a suspension of 38.6 g of N,N-bis(2-chloroethyl)amine hydrochloride in 265 ml of xylene heated to 100° C. The reaction mixture is heated at 140° C. for 12 hours and, after cooling, filtered over a frit. The filtrate is concentrated and then purified by flash chromatography (eluant CH2Cl2/AcOEt: 95/5) to yield the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06566364B2 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-1d5c6a4690ba4ac9a3d0f4173cf4b2d9 |
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| Source note | uspto-grants-2003_05 |
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