HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413278Generated: October 27, 2026
Phosphorus oxychloride → 2-Chloro-4-methyl-5-nitropyridine
https://huagongshe.com/reaction/413278
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178429283 | HCID 178429283 | — |
| Product | 2-Chloro-4-methyl-5-nitropyridine | HCID 345364 | — |
Reaction Steps
22.3 g of 2-hydroxy-4-methyl-5-nitropyridine and 170 ml of POCl3 are mixed together and heated at 100° C. for 3 hours. The cooled reaction medium is poured onto ice to yield a beige precipitate of 2-chloro-4-methyl-5-nitropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06566364B2 |
|---|
| Source dataset | uspto-grants-2003_05 |
|---|
| ORD ID | ord-342a9218a4d3440da53e98a9b77f0ce3 |
|---|
| Source note | uspto-grants-2003_05 |
|---|
