HCID 22390751, compound → HCID 22390789, compound

HRID 413282Notes

Reaction equation

HRID 413282 reaction equation
[N:1]1([S:10]([N:13]2[CH2:17][CH2:16][O:15]C2=O)(=[O:12])=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>[OH-].[Na+].C(O)C>[OH:15][CH2:16][CH2:17][NH:13][S:10]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1)(=[O:12])=[O:11]

Participants

4

Reactant 1

HCID 22390751HCID 22390751, compound

Product 1

HCID 22390789HCID 22390789, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

The product of Step 1 is dissolved in a solution of 3.2 g of sodium hydroxide in 80 ml of ethanol. After stirring for 48 hours at ambient temperature, the mixture is filtered. The filtrate is concentrated under reduced pressure, taken up in dichloromethane and washed with water. After drying and filtration, the organic phase is concentrated under reduced pressure, allowing the expected product to be obtained.

Workup

  1. filtrationthe mixture is filtered
  2. concentrationThe filtrate is concentrated under reduced pressure
  3. washwashed with water
  4. customAfter drying
  5. filtrationfiltration
  6. concentrationthe organic phase is concentrated under reduced pressure
  7. customto be obtained

Sources & evidence

ORD record
ord-4e3243e54d01441ca381c8d1fa23fc3b
Source dataset
uspto-grants-2003_05
Patent number
US06566364B2

Reaction notes

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