HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-benzyl-1H-pyrazole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-Pyrazole-3-carbaldehyde | HCID 12218383 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-benzyl-1H-pyrazole-3-carbaldehyde | HCID 11401199 | 61.9% |
Reaction Steps
To a solution of benzyl bromide (0.29 g) in N,N-dimethylformamide (9 ml) was added 1H-pyrazole-3-carboxaldehyde (0.15 g) and potassium carbonate (0.24 g). The mixture was stirred at room temperature for 24 hours, silica gel was added, the solvent removed by evaporation and the crude material purified by chromatography (isohexane:ether, 2:1) to give the product as an oil (0.18 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566376B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-6d33378c29d04b489b7fbd4671e4aa97 |
| Source note | uspto-grants-2003_05 |