Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 9805417 | HCID 9805417 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 9935064 | HCID 9935064 | 46.8% |
Reaction Steps
The product of Example 19 (0.03 g) was dissolved in N,N-dimethylformamide (2 ml), N,N-carbonyldiimidazole (0.020 g) was added and the solution heated at 60° C. for 2 hours and cooled. Aqueous ammonia solution (1 ml) was added and the mixture stirred at room temperature for 16 hours. Brine and ethyl acetate were added, the organic phase was separated, dried and the solvent removed by evaporation to give a solid. Trituration under ether gave the product as a solid (0.014 g), m.p. 227-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06566376B1 |
|---|
| Source dataset | uspto-grants-2003_05 |
|---|
| ORD ID | ord-b72fe72a344443c282b0a665ed4414e1 |
|---|
| Source note | uspto-grants-2003_05 |
|---|
