Ethanol → N-{1,1-Dimethyl-2-[4-(2-methyl-thiazol-4-yl)phenyl]-ethyl}-2,2,2-trifluoroacetamide

Participants

Reaction Conditions

Reaction Steps

In a round-bottomed flask, N-[2-(bromoacetyl-phenyl)-1,1-dimethyl-ethyl]-2,2,2-trifluoroacetamide (388 mg, 1.06 mmol) and thioacetamide (80 mg, 1.06 mmol) were dissolved in ethanol (10 ml), and the mixture was heated to about 80° C. for about two and one-half hours. The reaction mixture was then concentrated in vacuo to an oil which was carried into the next reaction without further purification. LRMS ([M+1]+)=343.2.

Provenance & Evidence