HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Methylbenzhydrol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | 2-(Benzyloxy)-[1,1'-biphenyl]-3-carbaldehyde | HCID 21840960 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Methylbenzhydrol | HCID 95659 | — |
Reaction Steps
A solution of 15 (1.44 g, 5 mmol, 1.0 equiv) and o-anisidine (16) (0.62 g, 0.56 mL, 5 mmol, 1.0 equiv) in toluene (15 mL) was refluxed overnight with H2O removal (Dean-Stark trap). The mixture was cooled to room temperature and concentrated under reduced pressure to give crude 5 as a yellow oil that was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530593B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-3d3bd0893a8f46feb24acb951ac1549d |
| Source note | uspto-grants-2013_09 |