HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-Amino-2-methyl-butyric acid methyl ester hydrochloride → (R)-Methyl 2-amino-2-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-Amino-2-methyl-butyric acid methyl ester hydrochloride | HCID 13018906 | — |
| Reactant | 3,5-dichloro-N-[(3R)-1-chloro-3-methyl-2-oxopentan-3-yl]-4-methylbenzamide | HCID 54316792 | — |
| Product | (R)-Methyl 2-amino-2-methylbutanoate | HCID 7144315 | — |
Reaction Steps
The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-chloro-1-ethyl- 1-methyl-2-oxopropyl)-3,5-dichloro-4-methylbenzamide (mp. 155.5-156° C., [α]D=+4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566403B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-825ca944dcd54cac9f4921afda03e388 |
| Source note | uspto-grants-2003_05 |