Methyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoate → 2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[(6-chloro-2-benzoxazolyl)thio]-pentanoic Acid

HRID 413385Notes

Reaction equation

HRID 413385 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[O:8][C:4]=2[CH:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([S:26]([NH:29][CH:30]([CH2:35][CH:36]3[O:38][CH2:37]3)[C:31]([O:33]C)=[O:32])(=[O:28])=[O:27])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[CH:22][C:23]([S:26]([NH:29][CH:30]([CH2:35][CH:36]([OH:38])[CH2:37][S:9][C:7]3[O:8][C:4]4[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=4[N:6]=3)[C:31]([OH:33])=[O:32])(=[O:27])=[O:28])=[CH:24][CH:25]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 12073922Methyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoateHCID 178527788HCID 178527788, compound

Product 1

HCID 235083092-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[(6-chloro-2-benzoxazolyl)thio]-pentanoic Acid

Procedure

Example 37 is prepared from 6-chloro-2-benzoxazolethiol and 1d using the procedure described for compound 20.

Sources & evidence

ORD record
ord-33f37e02a9714945a84099cb24ba9bfa
Source dataset
uspto-grants-2003_05
Patent number
US06566381B1

Reaction notes

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