Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413397Generated: October 26, 2026

p-Fluorotoluene-alpha-thiol → 2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[[(4-fluorophenyl)methyl]thio]-pentanoic Acid

https://huagongshe.com/reaction/413397

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Fluorotoluene-alpha-thiolHCID 85171—
ReactantMethyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoateHCID 12073922—
Product2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[[(4-fluorophenyl)methyl]thio]-pentanoic AcidHCID 23508249—

Reaction Steps

Example 51 is prepared from 4-fluorobenzylmercaptan and 1d using the procedure described for compound 20.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06566381B1
Source datasetuspto-grants-2003_05
ORD IDord-af502ecba729485dbc7aeb2069b1b8c4
Source noteuspto-grants-2003_05