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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413400Generated: October 29, 2026

Methyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoate → 2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[pyrimidin-2-yloxy]-pentanoic Acid

https://huagongshe.com/reaction/413400

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoateHCID 12073922—
ReactantHCID 178517760HCID 178517760—
Product2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[pyrimidin-2-yloxy]-pentanoic AcidHCID 23508237—

Reaction Steps

Example 56 is prepared from 2-hydroxypyrimidine and 1d using the procedure described for compound 20.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06566381B1
Source datasetuspto-grants-2003_05
ORD IDord-274d1c77af5f4af281f140cec55b7446
Source noteuspto-grants-2003_05