Hydrochloric Acid → HCID 18533202, compound

Participants

Reaction Steps

2-Methyl-propane-2-sulfinic acid [5-(3-tert-butoxy-benzyloxy)-1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-pentyl]-amide (A) (0.396 g, 0.58 mmol) was dissolved in methanol (15 mL) and treated with 4M HCl in dioxane (9 mL). After 1 h, the reaction mixture was concentrated in vacuo, azeotroped with CH2Cl2 (3×), rinsed with CH2Cl2, and the solid collected to give enantiomer A of the title compound. MS (M+1) 409. Using the same procedure, diastereomer B (Step D) (0.110 g, 0.161 mmol) gave enantiomer B of the title compound.

Provenance & Evidence