HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-3-(chloromethyl)-5-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Chloro-5-methylpyridin-3-yl)methanol | HCID 12056721 | — |
| Product | 2-Chloro-3-(chloromethyl)-5-methylpyridine | HCID 11206082 | — |
Reaction Steps
comprising reacting 2-chloro-3-hydroxymethyl-5-methylpyridine with thionyl chloride to give 2-chloro-3-chloromethyl-5-methylpyridine, followed by reacting the 2-chloro-3-chloromethyl-5-methylpyridine thus obtained with 2-nitroimino-1,3-diazacyclopentane in the presence of a base and an organic solvent, to give 1-(2-chloro-5-methyl-3-pyridylmethyl)-2-nitroiminoimidazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06566528B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-ba8a223b92544fb29e02e2c44799e391 |
| Source note | uspto-grants-2003_05 |