Triethylamine → HCID 11256325, compound

Participants

Reaction Steps

To a stirred solution of (4-cyano-2-hydroxymethylphenyl)(4-fluorophenyl)methanol (9.2 g, 0.037 mol) and triethylamine (4.0 g, 0.04 mol) was added pivaloyl chloride (4.2 g, 0.39 mol). After stirring for 60 minutes the reaction mixture was poured onto ice, extracted with diethyl ether (2×75 mL), dried (MgSO4), and concentrated under reduced pressure to give a colourless oil (12.0 g). The compound was purified by chromatography (eluent hexane/ethyl acetate 1:9 to give the title compound (8.2 g, 70%).

Provenance & Evidence