Phenylacetyl chloride → Phenylacetic Acid

Participants

Reaction Conditions

Reaction Steps

Mix 2-ethyl-1-hexanol (6.5 g, (5 mol), triethylamine (50.5 g, 0.5 mol) and methylene chloride (50 mL). Add, by dropwise addition, 2-phenylacetyl chloride (5 mol) and warm to 50° C. Stir a zoom temperature overnight, filter and wash the filtercake with methylene chloride (50 mL). Combine the organic phases and wash with it aqueous hydrochloric acid (50 mL) and water. Dry (MgSO4), evaporate the solvent in vacuo and purify by distillation to give 2-phenylacetic acid, 2-(2-ethylhexy)1 ester.

Provenance & Evidence