Hydrochloric Acid → HCID 53687165, compound

Participants

Reaction Steps

Mix 2-(4-(4-chloro-1-oxobutyl)-phenyl-2-methyl propanol acetate, concentrated hydrochloric acid (555 mL), and ethanol (2.5) and reflux for 2.5 hours under a nitrogen atmosphere. Evaporate the solvent in vacuo and take the residue up in methylene chloride (1L). Wash sequentially with water (2×400 mL), aqueous potassium carbonate (10%, 200 mL) and water (300 mL). Evaporate the solvent in vacuo to give the title compound as a light-brown oil (200 g, 90%).

Provenance & Evidence