反应详情

To a suspension of 2-aminoisobutyric acid (25.0 g, 243 mmol) in methanol (300 mL) was added thionyl chloride (27.0 mL, 43.0 g, 365 mmol) and the reaction was heated at reflux for 12 hours. The resulting solution was concentrated and triturated with diethyl ether-tetrahydrofuran to yield the product as a white powder, 29.8 g (80%).

1. temperaturethe reaction was heated
2. temperatureat reflux for 12 hours
3. concentrationThe resulting solution was concentrated
4. customtriturated with diethyl ether-tetrahydrofuran