Hydrochloric Acid → 4'-(cis-9-Octadecenyloxy)-4-biphenylcarboxylic acid

HRID 413627ノート

反応式

HRID 413627 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]/[CH:26]=[CH:27]\[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)=[O:4].O.[OH-].[Li+].Cl>O>[CH2:18]([O:17][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=2)=[CH:16][CH:15]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]/[CH:26]=[CH:27]\[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 70012153Methyl-4'-(cis-9-octadecenyloxy)-4-biphenylcarboxylate

生成物 1

HCID 700113904'-(cis-9-Octadecenyloxy)-4-biphenylcarboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Water (approximately 15 ml) was added to a solution of ester 28b (486 mg, 1.00 mmol) in 50 ml of an 80/20 (v/v) (methanol/THF) solution, until it remained milky white with vigorous stirring. To this suspension was added lithium hydroxide monohydrate (213 mg, 5.1 mmol), the reaction mixture was refluxed overnight and then was acidified with concentrated HCl. Water (approximately 20 ml) was added and the solution was cooled, filtered, washed several times with water, and air dried, yielding 422 mg (89%) of a white waxy powder.

後処理

  1. temperaturethe reaction mixture was refluxed overnight
  2. temperaturethe solution was cooled
  3. filtrationfiltered
  4. washwashed several times with water, and air
  5. customdried
  6. customyielding 422 mg (89%) of a white waxy powder

出典と根拠

ORDレコード
ord-dca386232c334862a3b4174f324e5e83
出典データセット
uspto-grants-2003_05
特許番号
US06569504B1

反応ノート

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