Phenol → Methyl-4-(trans-2-decenyloxy)-benzoate

HRID 413629ノート

反応式

HRID 413629 の反応式
C1(O)C=CC=CC=1.C(O)/C=C/CCCCCCC.CCOC(/N=N/C(OCC)=O)=O.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41]/[CH:42]=[CH:43]/[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

参加物

6

反応物 4

HCID 996PhenolHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 53649422-Decenol, (2E)-HCID 5462977Diethyl azodicarboxylate

生成物 1

HCID 18521070Methyl-4-(trans-2-decenyloxy)-benzoate収率 65%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Phenol 34 (486 mg, 3.2 mmol), 2-decenol 26g (500 mg, 3.2 mmol), TPP (965 mg, 3.68 mmol), and DEAD (641 mg, 3.68 mmol) in 32 ml ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc). Evaporation of solvent yielded 603 mg (65%) of colorless needles.

後処理

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of solvent

出典と根拠

ORDレコード
ord-3ccde8b6eb0e44c180f0d1201683a9ce
出典データセット
uspto-grants-2003_05
特許番号
US06569504B1

反応ノート

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