HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl-4-(trans-4-decenyloxy)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl 4-(octadecyloxy)benzoate | HCID 4189536 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | Dec-4-en-1-ol | HCID 5702619 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl-4-(trans-4-decenyloxy)-benzoate | HCID 18521044 | 80% |
Reaction Steps
DEAD (641 mg, 3.68 mmol), phenol 34 (487 mg, 3.2 mmol), alcohol 26i (500 mg, 3.2 mmol), and TPP (966 mg, 3.68 mmol) in 16 ml anhydrous ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc). Evaporation of the solvent yielded 748 mg (80%) of colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569504B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-aabf4a53aa2e4328af39e7245153793d |
| Source note | uspto-grants-2003_05 |