Hydrochloric Acid → (S)-4'-(1-Methylnonyloxy)-3'-(nitro)-4-biphenylcarboxylic acid

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Reaction Steps

Ester 41b (390 mg, 0.94 mmol) was dissolved in 3. ml THF and 15 ml methanol. Water was added with vigorous stirring until the solution remained cloudy, followed by the addition of lithium hydroxide monohydrate (56 mg, 1.30 mmol). After refluxing overnight, the solution was acidified with concentrated HCl and extracted with ether. The organic layer was washed with brine and dried over MgSO4. Evaporation of the solvent yielded 323 mg (86%) of a yellow solid.

Provenance & Evidence