Ethanol hydrochloride → HCID 136051886, compound

Participants

Reaction Steps

Compound 43b (143 mg, 0.57 mol), compound 51a (161 mg, 0.57 mmol), 0.1M aqueous sodium nitrite (5.6 ml), and pyridine (1.8 ml) in 15 ml of a 15% HCl/ethanol solution were reacted according to the procedure for compound 52a. The crude product was adsorbed onto silica gel and purified via flash chromatography with gradual elutions from 85/10/5 to 75/20/5 (Hex/EtOAc/dichloromethane). Evaporation of solvent yielded 199 mg (64%) of a metallic green solid.

Provenance & Evidence