HCID 18521101, compound → HCID 135991626, compound

Participants

Reaction Steps

Compound 43a (388 mg, 1.46 mmol), compound 51b (392 mg, 1.46 mmol), 0.1M aqueous sodium nitrite (14.5 ml), and pyridine (4.5 ml) in 39 ml of a 15% HCl/ethanol solution were reacted according to the procedure for compound 52a. The crude product was adsorbed onto silica gel and purified via flash chromatography with gradual elutions. from 90/5/5 to 75/20/5 (Hex/EtOAc/dichloromethane). Recrystallization from hexanes yielded 370 mg (46%) of a metallic green solid.

Provenance & Evidence