HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → HCID 20590354, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Rebeccamycin | HCID 73110 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20590354 | HCID 20590354 | — |
Reaction Steps
1 equivalent of potassium carbonate and 1 equivalent of tosyl chloride are added to a solution of 1.7 mmol of rebeccamycin in 200 ml of tetrahydrofuran. After 48 hours' reflux and concentration under reduced pressure, chromatography of the residue over silica gel (cyclohexane/ethyl acetate 70/30) enables the expected product to be isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569858B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-72192b0639994cef88f0ad8e22862204 |
| Source note | uspto-grants-2003_05 |