Methanesulfonic Acid → HCID 20589484, compound

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Reaction Steps

The above 3-piperidinecarboxylic acid (2.84 g, 5.3 mmol) was dissolved in dichloromethane (200 ml), methanesulfonic acid (0.5 ml) was added and the resulting mixture was heated at reflux temperature for 2 days. The mixture was allowed to cool and was then concentrated in vacuo. The residue was dissolved in water (50 ml) and extracted with dichloromethane (4×50 ml). The combined organic extracts were concentrated in vacuo. The residue was purified by column chromatography on silica gel using a mixture of dichloromethane and methanol (9:1) as eluent. This afforded after evaporation of the solvent 0.74 g of the title compound.

Provenance & Evidence