Hydrochloric Acid → HCID 10183353, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-phenyl-5-(5-phenyl-benzofuran-2-ylmethoxy-carbonylamino)-pyrimidine-4-carboxylic acid methyl ester (0.956. g, 1.99 mmol) in THF (20 mL), was added lithium hydroxide monohydrate (0.167 g, 3.99 mmol) in 4 ml of water. The mixture was stirred at 5° C. for 2 h, and 1N HCl was added to adjust the pH to 2. The solvents were removed in vacuo and the resulting suspension was filtered. Recrystallisation of the white crude solid gave 0.82 g of 2-phenyl-5-(5-phenyl-benzofuran-2-ylmethoxycarbonylamino)-pyrimidine-4-carboxylic acid, mp: 184-185° C.

Provenance & Evidence