HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413709Generated: October 26, 2026
Glutaric anhydride → 5-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid
https://huagongshe.com/reaction/413709
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N-methyl-N-phenyl-2-(piperazin-1-yl)acetamide | HCID 2737187 | — |
| Product | 5-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid | HCID 69503357 | — |
Reaction Steps
1.517 g of glutaric anhydride and then 1.715 g of N-[2-(piperazin-1-yl)acetyl]-N-methylaniline are added to 15 cm3 of dioxane. After stirring for 19 hours at 25° C., the white precipitate formed is filtered on No. 4 sintered glass, rinsed with dioxane and then with diethyl ether and then dried at 20° C. (90 Pa) to give 2 g of 5-[4-(methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid in the form of a white solid which is used as it is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06569854B1 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-1708bc3c5bfe46e8b9270b2537b34c55 |
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| Source note | uspto-grants-2003_05 |
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