HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178501234, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Morpholinebutanoic acid | HCID 79872 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 178501209 | HCID 178501209 | — |
| Catalyst | HCID 178526939 | HCID 178526939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178501234 | HCID 178501234 | 73.8% |
Reaction Steps
The procedure is carried out in a manner similar to that described in Example 63, but starting with 4.20 g of methyl cis-4-aminocyclohexane-1-carboxylate hydrochloride, 4.0 g of 4-morpholinobutyric acid, 50 mg of hydroxybenzotriazole hydrate, 11.2 cm3 of triethylamine, 200 cm3 of dichloromethane and 4.2 g of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride. After a treatment similar to that in Example 60, the crude product is purified by flash chromatography [eluent: dichloromethane/methanol (95/5 by volume)] to give 5.0 g of methyl cis-4-(4-morpholinobutyrylamino)-1-cyclohexanecarboxylate in the form of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569854B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-ae1753f6db8d440aa460b80da9b16d44 |
| Source note | uspto-grants-2003_05 |