HCID 18521921, compound → HCID 18521919, compound

HRID 413734Notes

Reaction equation

HRID 413734 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([NH2:22])=[CH:20][CH:21]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

Participants

3

Reactant 1

HCID 18521921HCID 18521921, compound

Product 1

HCID 18521919HCID 18521919, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in a manner similar to that described for Example D(1). Catalytic reduction of the title compound from Example A(8) (i.e., [4-amino-2-(4-nitro-phenylamino)-thiazol-5-yl]-phenyl-methanone, 450 mg, 1.32 mmol) gave, after recrystallization from ethanol, 120 mg (29% yield) of orange powder, mp 167-169° C.

Workup

  1. customThe title compound was prepared in a manner similar to

Sources & evidence

ORD record
ord-66a8eda3a5ea4c39b683e418b2489664
Source dataset
uspto-grants-2003_05
Patent number
US06569878B1

Reaction notes

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