HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → n-(4-Dimethylaminobenzyl)-2-nitro-4-trifluoromethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene | HCID 8462 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(aminomethyl)-N,N-dimethylaniline dihydrochloride | HCID 2734633 | — |
| Solvent | Water | HCID 962 | — |
| Product | n-(4-Dimethylaminobenzyl)-2-nitro-4-trifluoromethylaniline | HCID 8461356 | — |
Reaction Steps
A mixture of 4-chloro-3-nitrobenzotrifluoride (5.05 g, 22.4 mmol), 4-(dimethylamino)-benzylamine dihydrochloride (5.0 g, 22.4 mmol), potassium carbonate (9.29 g, 76.2 mmol) and dimethylformamide (60 ml) was stirred at room temperature for 3 days. Water (60 ml) was added and the mixture was stirred for 0.5 h followed by filtration. The crystalline product was triturated with petroleum ether. Yield 6.08 g, 80%. M.p. 158-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569880B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-cff53d2bacd042e4836ae7aac2020d91 |
| Source note | uspto-grants-2003_05 |