反应详情

A mixture of 3-aminobenzotrifluoride (15.0 g, 93.1 mmol), cyanogen bromide (12.2 g, 129 mmol) and diethyl ether was stirred at reflux for 40 h. The crude mixture was purified by chromatography using silica gel and a mixture of petroleum ether and dichloromethane as eluent (1:1). The product was isolated as the free base. Yield 5.2 g, 25%.

1. temperatureat reflux for 40 h
2. customThe crude mixture was purified by chromatography
3. additiona mixture of petroleum ether and dichloromethane as eluent (1:1)
4. customThe product was isolated as the free base