反应详情

温度

150 °C

A mixture of 3-cyanamidobenzotrifluoride (1.20 g, 6.45 mmol) and 4-chlorobenzylamine hydrochloride (1.26 g, 7.09 mmol) was stirred at 150° C. for 40 h. Dichloromethane (100 ml) was added and the mixture was washed with saturated aqueous sodium hydrogen carbonate (100 ml). The organic phase was purified by chromatography using silica gel and a mixture of methanol (10%) and dichloromethane as eluent. The product was isolated as the free base. Yield 1.05 g, 50%. M.p. 103-105° C.

1. washthe mixture was washed with saturated aqueous sodium hydrogen carbonate (100 ml)
2. customThe organic phase was purified by chromatography
3. additiona mixture of methanol (10%) and dichloromethane as eluent
4. customThe product was isolated as the free base