HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 413749Generated: October 28, 2026
Dimethylformamide → HCID 18522082, compound
https://huagongshe.com/reaction/413749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-Benzimidazol-2-amine, 5-chloro- | HCID 21527 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18522082 | HCID 18522082 | — |
Reaction Steps
A mixture of 2-amino-5-chloro-benzimidazole (9.4 g, 56.1 mmol), 4-chlorobenzylchloride (9.93 g, 61.7 mmol), potassium carbonate (15.5 g, 112 mmol) and dimethyl formamide (150 ml) was stirred at 50° C. for 20 h. Water (150 ml) was added and the product was filtered off. The crude product was purified by chromatography using silica gel and a mixture of ethanol (5%) and dichloromethane as eluent. The product was isolated as the free base. Yield 0.37 g, 2%. M.p. 175-177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06569880B2 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-9417fcc6daed47fb85cfeaaeefcd26c6 |
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| Source note | uspto-grants-2003_05 |
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