HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → ethyl 3,5-dimethyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | (4-Methylphenyl)hydrazine | HCID 10875 | — |
| Reactant | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 3,5-dimethyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate | HCID 2766289 | — |
Reaction Steps
Similar to Example 1, p-tolylhydrazine (10 mmol, 1.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a solution of 50% pyridine in ethanol. The solvents were removed under vacuum. The named product was purified over silica gel (m.p. 47° C.-49° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569885B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-b9beaae533e94881b854929806ca5cdf |
| Source note | uspto-grants-2003_05 |