HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3,5-dimethyl-1-m-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| Reactant | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-dimethyl-1-m-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9878335 | — |
Reaction Steps
Similar to Example 1, equimolar amounts of m-tolylhydrazine hydrochloride and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of a 50% pyridine in ethanol. The resulting oil was purified by flash chromatography to yield the named product as a solid (m.p. 46.5° C.-47.5° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569885B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-062186bdcd99457cb32fc66f5c1d527f |
| Source note | uspto-grants-2003_05 |