反应详情

温度

25 °C

To a solution of 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione (20.0 g) in acetonitrile (200 ml) was added cesium carbonate (21.0 g), followed by the addition of bromoacetic acid t-butyl ester (7.4 ml). The resulting mixture was stirred at 25° C. for 3 hours. To the reaction mixture was added water and the organic layer was separated and concentrated in vacuo. The residue was extracted with toluene and the extract was washed with diluted hydrochloric acid and water and concentrated in vacuo to afford the desired compound (24.9 g).

1. customthe organic layer was separated
2. concentrationconcentrated in vacuo
3. extractionThe residue was extracted with toluene
4. washthe extract was washed with diluted hydrochloric acid and water
5. concentrationconcentrated in vacuo