Ethyl Acetate → 2-(4-((2,4-Dioxothiazolidin-5-YL)methyl)phenoxy)acetic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2,4-dioxo-3-tritylthiazolidin-5-ylmethyl)phenoxyacetic acid t-butyl ester (6.2 g) (obtained in Reference Example 5) in toluene (25 ml) was added p-toluenesulfonic acid monohydrate (204 mg). The resulting mixture was heated under reflux for 3 hours. Ethyl acetate (10 ml) was added while heating and then the mixture stirred at 25° C. for 1.5 hours. The resulting crystals were collected by filtration to afford the desired compound (2.5 g).

Provenance & Evidence