HCID 22393040, compound → HCID 86592591, compound

HRID 413857Notes

Reaction equation

HRID 413857 reaction equation
[C:1]([CH:4]([CH:8]([CH3:10])[CH3:9])[C:5]([OH:7])=O)(=[S:3])[CH3:2].[NH2:11][C@H:12]([C:14]([C:16]1([NH2:35])[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]2[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=2[N:18]([CH3:33])[C:17]1=[O:34])=[O:15])[CH3:13]>>[C:1]([CH:4]([CH:8]([CH3:10])[CH3:9])[C:5]([NH:11][C@H:12]([C:14]([C:16]1([NH2:35])[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]2[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=2[N:18]([CH3:33])[C:17]1=[O:34])=[O:15])[CH3:13])=[O:7])(=[S:3])[CH3:2]

Participants

3

Reactant 2

HCID 22393040HCID 22393040, compoundHCID 53952692HCID 53952692, compound

Product 1

HCID 86592591HCID 86592591, compound

Procedure

Following General Procedure D above using 2-thioacetyl-3-methyl butanoic acid (Coric et al., J. Med. Chem. 39, 1210 (1996)) and 3-(L-alaninyl)-amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one, as described in Example 8-B, the title compound was prepared.

Sources & evidence

ORD record
ord-d85a616cf2e44c9fbed2c03d5fb09d50
Source dataset
uspto-grants-2003_05
Patent number
US06569851B1

Reaction notes

Loading…