Acetic Acid → HCID 178456866, compound

Participants

Reaction Steps

A 5-liter flask equipped with a reflux condenser, thermometer, and mechanical stirrer was charged with 251.8 g (1.75 mole) of N5-Propyl-1H-[1,2,4]triazole-3,5-diamine, 1.75 liter of toluene, 203.4 g (1.92 mole) of benzaldehyde and 5.2 g (0.087 mole) of acetic acid and then heated to reflux for 1˜3 hours. During the reaction, water was formed as by-product and removed azeotropically. After checking the end of the reaction by LC (peak area of N5-Propyl-1H-[1,2,4]triazole-3,5-diamine is less than 1%), the mixture was cooled down and gave the crude N3-Benzylidene-N5-propyl-1H-[1,2,4]triazole-3,5-diamine suspension solution, which was used for the next stage without purification.

Provenance & Evidence