Ethanolamine → HCID 9913037, compound

Participants

Reaction Steps

To a solution of [4-oxo-(5-trifluoromethyl-benzothiazol-2-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid (419 mg, 1.0 mmol) in acetone (20 mL) was added ethanolamine (611 mg, 10.0 mmol). After stirring at ambient temperature for 1.0 hour, the mixture was evaporated to a semi-solid, which was crystallized from ethanol:diethyl ether (1:4) to afford the title compound as a white crystalline solid (460 mg, 95%). mp: 119-121° C.; 1H NMR (D2O, 350 MHz): δ 3.30 (m, 2H), 3.66 (s, 2H), 3.79 (s, 6H), 5.47 (s, 2H), 7.19 (m, 1H), 7.48-7.71 (m, 5H), 7.99 (m, 1H).

Provenance & Evidence